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Relation of Aortic Stiffness to Left Ventricular Remodelling in Younger Adults with Type 2 Diabetes.


  • Specialist Medicine


Document Type

Published Date

  • 2018-04


  • Individuals with type 2 diabetes have a three-to-five-fold increased risk of developing heart failure. Diabetic cardiomyopathy is typified by left ventricular (LV) concentric remodelling, which is a recognised predictor of adverse cardiovascular events. Although the mechanisms underlying LV remodelling in type 2 diabetes are unclear, progressive aortic stiffening may be a key determinant. The aim of this study was to assess the relationship between aortic stiffness and LV geometry in younger adults with type 2 diabetes, using multiparametric cardiovascular magnetic resonance imaging. We prospectively recruited 80 adults (aged 18-65 years) with type 2 diabetes and no cardiovascular disease and 20 age- and sex-matched healthy controls. All subjects underwent comprehensive bio-anthropometric assessment and cardiac magnetic resonance imaging, including measurement of aortic stiffness by aortic distensibility (AD). Type 2 diabetes was associated with increased LV mass, concentric LV remodelling and lower AD compared with controls. On multivariable linear regression, AD was independently associated with concentric LV remodelling in type 2 diabetes. Aortic stiffness may therefore be a potential therapeutic target to prevent the development of heart failure in type 2 diabetes.
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